11 Comments
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Experimental Fat Loss's avatar

Very interesting theory. I suppose there's an infinite number of potential offenders, just in terms of "forever plastics" there's thousands I think.. can this ALDH pathway thing be measured?

I have never had bad inflammation in anything; but have always gained fat extremely easily. Maybe I'm just super good at locking stuff away in the vault haha.

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Matt Quinn's avatar

The best indicators for ALDH would be probably serum for HNE and also looking at your DNA.

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Leo Abstract's avatar

This is a fun theory, highly plausible. The questions would be:

1) how much of a causative effect does this have - 1%? 10%? 80%?

2) what would this predict that we can test?

3) do we need to add 'epicycles' to explain?

4) would this happen in the absence of PUFA?

4a) that is, is it challenged by noticing the very high levels of smoke exposure they were experiencing didn't cause any weight gain at all in the old siberian women who were too crippled or blind to leave the dwelling, and who sat inside in the smoke making leather goods by hand all day every day?

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Matt Quinn's avatar

One, it's going to depend on a person

Two, you could probably predict that removing the inputs and somebody's food noise would go away, and then adding them back would bring back the food noise.

Three not sure

Four, yes. In a modern environment, I think there are other things that can be classed as pollutants.

An old Siberian woman sat inside, likely doesn't have the other environmental pressures than smoke.

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UnvaxxedCanadian's avatar

I’ve seen some suggestions that the GLP1’s are unleashing hell when the toxins and Omega 6’s start to be burned for fuel.

I myself fluctuate between 150-159 and diet Feb 1 to get ripped around May with just eating less and reducing carbs during the week and eating “normally” on the weekends. I’ve also been lifting for 30 years and eating organic and all that. Not normal by any means. Used to be a lot bigger but that is a young man’s game though RFKjr is jacked for sure.

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Matt Quinn's avatar

Based on the study cited here, GLP-1s are definitely unleashing hell on people's bodies.

What's worse is that GLP-1s slow gastric emptying and mess up your bile system as well. So they're not detoxing anywhere near the acceptable rate.

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rt's avatar

I have two questions.

1. How can you tell that exercise degrades organic pollutants in circulation?

2. Is sweating per se good for detoxing? How about non-exercise-related sweating, like for temperature?

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Matt Quinn's avatar

1. I'm not sure I understand what you're actually asking.

Are you asking how can you tell if exercise is working, or what scientific basis is there for this idea?

2. Yes, (sauna), non-exercise related sweating is also fantastic.

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rt's avatar

1. Sorry, I'm a non-native speaker. I wanted to ask what is the scientific basis for the idea that exercise degrades organic pollutants in circulation.

2. Thank you, this is very interesting to me.

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Keymaker's avatar

Crucial.

A lot of the genius of Tim Ferriss slow carb diet is that it hits lots of theories of weight loss simultaneously, including detox.

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Matt Quinn's avatar

The challenge with any diet dogma, though, is that it only works for some people. And you never really hear about the people that it works for.

A good amount of this is chalked up to genetics.

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